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You are here: Home / Archives for Alzheimer

Inflammation as a New Therapeutic Approach For Alzheimer’s Disease

Inflammation as a New Therapeutic Approach For Alzheimer’s DiseaseIn the next several decades the number of Alzheimer’s patients will continue to dramatically increase. Various teams of researchers worldwide are feverishly investigating precisely how the illness develops.
Inflammation as a New Therapeutic Approach For Alzheimer’s Disease

A team of scientists under the guidance of the University of Bonn and University of Massachusetts (USA) and with the participation of the German Center for Neurodegenerative Diseases have discovered a new signaling pathway in mice which is involved in the development of chronic inflammation which causes nerve cells in the brain to malfunction and die off. The results are now being published in the renowned scientific journal “Nature”.

… [Continue Reading]

Filed Under: Alzheimer Tagged With: Alzheimer, Alzheimer disease, Inflammation

Brain Pacemakers Are Starting To Be Used To Fight Alzheimer’s Disease

brain-mri-lucia-zamoranoFor the very first times, surgeons at Johns Hopkins have used a brain-implanted pacemaker device to try to slow memory loss in a patient suffering from the early stages of Alzheimer’s. So far there’s only one patient with a memory-saving zapper, but a second is on the way along with about 40 others over the course of the next year, with the help of several other research institutes. After implantation, the pacemakers zap a part of the brain called the fornix with up to 130 blasts of electricity per second, all without disturbing the brain’s owner.

The researchers hope that this will be an effective solution at treating Alzheimer’s in and of itself, but if nothing else it should at least provide valuable information that could further other treatments as well. Johns Hopkins is currently accepting volunteers for the program, and hopefully those implants will give them—and all who follow—a fighting chance at hanging on to those precious memories.

Read more: ExtremeTech

Filed Under: Alzheimer Tagged With: Alzheimer disease

New Alzheimer’s drug studies offer patients hope

TRENTON, N.J. (AP) — For Alzheimer’s patients and their families, desperate for an effective treatment for the epidemic disease, there’s hope from new studies starting up and insights from recent ones that didn’t quite pan out.

If the new studies succeed, a medicine that slows or even stops progression of the brain-destroying disease might be ready in three to five years, said Dr. William H. Thies, chief medical officer of the Alzheimer’s Association. The group assists patients and caregivers, lobbies for more research and helps fund studies.

“The number of smart people working on this problem means to me we’ll begin to manage it better in the very near future,” Thies said. “It may be as short as three years away.”

That’s only if government and other sources provide tens of millions of dollars for additional research and more patients join clinical studies.… [Continue Reading]

Filed Under: Alzheimer

Second Bapineuzumab Trial Fails in Alzheimer’s

Pauline Anderson

A second phase 3 trial investigating bapineuzumab IV in patients with mild to moderate Alzheimer’s disease (AD) has been stopped, essentially spelling the end of the program to investigate this agent in patients with this type of dementia.

The 18-month, randomized, double-blind, multicenter studies were examining the efficacy and safety of bapineuzumab, a monoclonal antibody that targets beta-amyloid (Aß), in patients who carry the apolipoprotein E epsilon 4 (ApoE4) genotype and in those who do not.… [Continue Reading]

Filed Under: Alzheimer Tagged With: Alzheimer, Bapineuzumab

Ceramides in Blood May Signal Alzheimer’s Disease Risk

High levels of a family of lipids called ceramides in the blood may be predictive of developing Alzheimer’s disease, a new study suggests.

Women with the highest levels of ceramides had a 10-fold higher risk of developing Alzheimer’s compared with those with the lowest levels, said Michelle M. Mielke, PhD, from the Mayo Clinic, Rochester, Minnesota.

“The study is small — that’s a limitation, and it was a preliminary study. However, given the small sample size, to have hazard ratios that are near 10 was quite striking and we didn’t expect to see that at all,” Dr. Mielke told Medscape Medical News.… [Continue Reading]

Filed Under: Alzheimer Tagged With: Alzheimer, ceramides

Bapineuzumab Fails in Phase 3 Alzheimer’s Trial

Pfizer Inc has announced topline results of a phase 3 trial of bapineuzumab showing treatment failed to meet the co-primary endpoint of change in cognitive or functional performance versus placebo in patients with mild to moderate Alzheimer’s disease (AD) who are positive for the apolipoprotein E4 (ApoE4) risk allele.

Bapineuzumab is an investigational monoclonal antibody that targets amyloid-ß (Aß) under development by the Alzheimer’s Immunotherapy Program (AIP), a partnership between Janssen Alzheimer Immunotherapy R&D LLC (Janssen AI) and Pfizer Inc.… [Continue Reading]

Filed Under: Alzheimer Tagged With: Alzheimer, Bapineuzumab

DNA Mapping of Alzheimer’s Patients Gives Deep Dive View

Over the past 18 months, 81-year-old Bill Bunnell has visited the doctor a half-dozen times to take memory tests, provide blood samples, and undergo a spinal tap and imaging scans. It’s all part of the most extensive study ever conducted on Alzheimer’s.

Now researchers are about to take an even closer look at Bunnell, a retired engineer from Madison, Connecticut.

Working with $2 million in new grants to be announced this week, the researchers for the Alzheimer’s Disease Neuroimaging Initiative will, for the first time, start mapping the DNA of 800 participants in a study attempting to find the root causes of memory loss. The goal is to see if physical changes from Alzheimer’s can be matched to genetic disparities, which can then be compared with findings from healthy people like Bunnell.… [Continue Reading]

Filed Under: Alzheimer

Study finds drinking coffee can delay onset of Alzheimer’s

A study of senior citizens in Florida found that drinking coffee could delay the onset of or help prevent Alzheimer’s disease.

The study, carried out on adults over the age of 65 in Miami and Tampa, found that those with higher levels of caffeine in their blood avoided the onset of Alzheimer’s in the two- to four-year period they were monitored.

Dr. Chuanhai Cao, a neuroscientist at the University of South Florida College of Pharmacy, said, “These intriguing results suggest that older adults with mild memory impairment who drink moderate levels of coffee — about three cups a day — will not convert to Alzheimer’s disease or at least will experience a substantial delay before converting to Alzheimer’s.”… [Continue Reading]

Filed Under: Alzheimer Tagged With: Alzheimer, coffee

Is Coconut Oil Effective for Alzheimer Disease?

Response from Gayle Nicholas Scott, PharmD
Assistant Professor, Eastern Virginia Medical School, Norfolk, Virginia; Clinical Pharmacist, Chesapeake Regional Medical Center, Chesapeake, Virginia

Coconut oil and a related medical food, Axona® (Accera, Inc; Broomfield, Colorado), are being promoted as treatments for Alzheimer disease (AD). Obtained from the kernel of the coconut palm (Cocos nucifera),[1] coconut oil contains medium-chain fatty acids, predominately lauric acid but also caprylic, myristic, and palmitic acids. Medium-chain triglycerides are the esterified form of medium-chain fatty acids; the terms are often used interchangeably.[2] The active ingredient of Axona is caprylic triglyceride. In the published research available, the product is called AC-1202.… [Continue Reading]

Filed Under: Alzheimer Tagged With: Alzheimer

New Alzheimer’s Prevention Trial Part of US National Plan

May 18, 2012 — An ambitious National Alzheimer’s Plan announced this week by the Department of Health and Human Services to address the growing threat of Alzheimer’s disease (AD) in the United States includes funding for the first prevention trial in people genetically predisposed to develop early symptoms.

The double-blind, placebo-controlled study will test the drug crenezumab, an antibody that targets beta-amyloid, in a large extended family in Colombia, many of whom carry genetic risk mutations. Typically, cognitive impairment begins at around age 45 in affected individuals.… [Continue Reading]

Filed Under: Alzheimer

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