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You are here: Home / Archives for Alzheimer disease

MRI May Tell Alzheimer’s from Other Dementias

MRI of BrainThree-fourths of patients with Alzheimer’s disease or frontal-lobe degeneration had MRI-detected biomarker levels that correlated with the diagnoses, suggesting MRI has potential as a screening tool for the conditions, investigators reported.

MRI-predicted values for total tau and β-amyloid ratio (tt/Aβ) in gray matter correctly pinpointed the diagnosis in 75% of patients with genetically or neuropathologically confirmed diagnoses, according to Corey McMillan, PhD, of the University of Pennsylvania in Philadelphia, and colleagues. Predicted values also had good correlation with actual tt/Aβ measured in cerebrospinal fluid (CSF), they said.

The findings are consistent with previous in vivo and autopsy studies of CSF tt/Aβ, the group reported in the Jan. 8 issue of Neurology.

… [Continue Reading]

Filed Under: Alzheimer Tagged With: Alzheimer, Alzheimer disease, Dementia

Inflammation as a New Therapeutic Approach For Alzheimer’s Disease

Inflammation as a New Therapeutic Approach For Alzheimer’s DiseaseIn the next several decades the number of Alzheimer’s patients will continue to dramatically increase. Various teams of researchers worldwide are feverishly investigating precisely how the illness develops.
Inflammation as a New Therapeutic Approach For Alzheimer’s Disease

A team of scientists under the guidance of the University of Bonn and University of Massachusetts (USA) and with the participation of the German Center for Neurodegenerative Diseases have discovered a new signaling pathway in mice which is involved in the development of chronic inflammation which causes nerve cells in the brain to malfunction and die off. The results are now being published in the renowned scientific journal “Nature”.

… [Continue Reading]

Filed Under: Alzheimer Tagged With: Alzheimer, Alzheimer disease, Inflammation

Brain Pacemakers Are Starting To Be Used To Fight Alzheimer’s Disease

brain-mri-lucia-zamoranoFor the very first times, surgeons at Johns Hopkins have used a brain-implanted pacemaker device to try to slow memory loss in a patient suffering from the early stages of Alzheimer’s. So far there’s only one patient with a memory-saving zapper, but a second is on the way along with about 40 others over the course of the next year, with the help of several other research institutes. After implantation, the pacemakers zap a part of the brain called the fornix with up to 130 blasts of electricity per second, all without disturbing the brain’s owner.

The researchers hope that this will be an effective solution at treating Alzheimer’s in and of itself, but if nothing else it should at least provide valuable information that could further other treatments as well. Johns Hopkins is currently accepting volunteers for the program, and hopefully those implants will give them—and all who follow—a fighting chance at hanging on to those precious memories.

Read more: ExtremeTech

Filed Under: Alzheimer Tagged With: Alzheimer disease

Rare Mutation Triples Risk of Alzheimer’s

NIHA mutation found in about one in 200 Icelanders older than 85 raised the risk of developing Alzheimer’s disease threefold, researchers said.

The mutation, in an immunoregulatory gene known as TREM2, was more common in Alzheimer’s disease patients than in the general 85-and-older population in Iceland with an odds ratio of 2.91 (95% CI 2.09 to 4.09, P=3.42×10-10), reported Kari Stefansson, MD, PhD, of deCode Genetics in Reykjavik, Iceland, and colleagues.

Because of the gene’s function within the central nervous system, the mutation “may lead to an increased predisposition to Alzheimer’s disease through impaired containment of inflammatory processes,” the researchers wrote online in the New England Journal of Medicine.… [Continue Reading]

Filed Under: News Tagged With: Alzheimer disease

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