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You are here: Home / Archives for Stroke

CT angiography better predictor of coronary disease than stress test

Mra-mipCoronary CT angiography may be better than stress testing alone as a diagnostic tool for patients presenting with chest pain, according to the SCOT-HEART investigators.

Subsequent invasive angiography was less likely to show normal coronary arteries in patients diagnosed with coronary CT angiography results in lieu of stress testing data (0.96% versus 2.70% with stress testing, hazard ratio 0.39, 95% confidence interval 0.23-0.68). This group was also more likely to have confirmed obstructive coronary artery disease (CAD, 13.65% versus 11.10%, HR 1.29, 95% CI 1.08-1.55).

In addition, coronary CT angiography led to more use of preventive therapies (13.65% versus 3.57%, HR 4.03, 95% CI 3.12-5.20), David E. Newby, MD, of University of Edinburgh in the U.K., and colleagues reported online in the Journal of the American College of Cardiology.… [Continue Reading]

Filed Under: Stroke

Time is Essential to Spare Brain After Ischemic Stroke: Less than 3 Hours Window

StrokeThe Massachusetts General Hospital acute stroke imaging algorithm: an experience and evidence based approach.

The Massachusetts General Hospital Neuroradiology Division employed an experience and evidence based approach to develop a neuroimaging algorithm to best select patients with severe ischemic strokes caused by anterior circulation occlusions (ACOs) for intravenous tissue plasminogen activator and endovascular treatment.

… [Continue Reading]

Filed Under: Stroke Tagged With: stroke

Treat atrial fibrillation AF to prevent stroke

pradaxaPRADAXA 150 mg twice daily provided an additional 35% risk reduction of stroke/systemic embolism vs warfarin

  • Superior reduction of ischemic and hemorrhagic stroke vs warfarin
  • Similar rate of major bleeds‡ with PRADAXA vs warfarin
  • PRADAXA is the ONLY anticoagulant to demonstrate superior reduction of ischemic stroke vs warfarin
  • PRADAXA also demonstrated a lower rate of intracranial bleeding vs warfarin

Additional 35% risk reduction of stroke/systemic embolism vs warfarin. Protect the brain by reducing the risk of ischemic stroke.

Learn more at pradaxapro.com

Filed Under: Stroke Tagged With: atrial fibrillation

Can we reduce the risk of recurrent event after a TIA or minor stroke? New study shows benefit of Clopidogrel with Aspirine

Transient Ischemic AttackStroke is common during the first few weeks after a transient ischemic attack (TIA) or minor ischemic stroke. Combination therapy with clopidogrel and aspirin may provide greater protection against subsequent stroke than aspirin alone.

In a randomized, double-blind, placebo-controlled trial conducted at 114 centers in China, we randomly assigned 5170 patients within 24 hours after the onset of minor ischemic stroke or high-risk TIA to combination therapy with clopidogrel and aspirin (clopidogrel at an initial dose of 300 mg, followed by 75 mg per day for 90 days, plus aspirin at a dose of 75 mg per day for the first 21 days) or to placebo plus aspirin (75 mg per day for 90 days). All participants received open-label aspirin at a clinician-determined dose of 75 to 300 mg on day 1. The primary outcome was stroke (ischemic or hemorrhagic) during 90 days of follow-up in an intention-totreat analysis. Treatment differences were assessed with the use of a Cox proportional- hazards model, with study center as a random effect.

… [Continue Reading]

Filed Under: Stroke Tagged With: TIA, Transient Ischemic Attack

New Approaches to Monitor Stroke

stroke-monitoringStroke is a common, potentially devastating disease with potential high morbidity and mortality. Recognition at the onset of acute ischemic stroke is pivotal to changing outcomes such as intravenous thrombolysis. Stroke monitoring is a burgeoning field with various methods described and newer devices that aid in detecting acute or worsening ischemia that can lead to improved bedside and intensive care unit management. This article describes various methods of bedside stroke monitoring including newer techniques of intracranial pressure monitoring using the pressure reactivity index and compensatory reserve index to detect changes in autoregulatory states, noninvasive intracranial pressure monitoring, quantitative EEG with alpha–delta ratio, transcranial Doppler, methods of arteriovenous brain oxygen monitoring such as jugular venous oxygen and near-infrared spectroscopy, invasive brain oxygen probes such as LicoxTM (brain tissue O2), cerebral blood flow probe (CBF HemedexTM) and cerebral microdialysis.

… [Continue Reading]

Filed Under: Stroke Tagged With: stroke

New Ischemic Stroke Guidelines

guidelinesIschemic Stroke Guidelines released at the end of January 2013.

These guidelines were put together by an expert panel and touch on many aspects of acute stroke care, with a focus on ischemic stroke. The guidelines include dozens of recommendations. I am not going to talk about all of them today, but I would like to highlight some that are particularly important to treating clinicians.

First, the guidelines come out very strongly in favor of transporting patients with acute stroke to the nearest primary or comprehensive stroke center. This is a great idea because we know from numerous studies and analyses that care at these certified stroke centers really does make a difference in terms of improving outcomes and reducing complications. That is a very strong positive recommendation. In addition, the guidelines now say that these stroke centers should be certified by an independent body or agency, so we are moving away from the paradigm of self-certification [toward independent, objective certification], which is also a positive move.

… [Continue Reading]

Filed Under: Stroke Tagged With: Stroke Guidelines

More Evidence Dark Chocolate Is Cardioprotective

The blood pressure–lowering and lipid effects of dark chocolate could be an effective — and money-saving — strategy for preventing cardiovascular events in high-risk patients, a new study suggests.

“The findings of this study suggest that the blood pressure lowering and lipid effects of plain dark chocolate could represent an effective and cost effective strategy for the prevention of cardiovascular disease in people with metabolic syndrome (and no diabetes),” the researchers, with senior author Christopher M. Reid, PhD, CCRE Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, The Alfred Centre, Melbourne, Victoria, Australia, conclude.… [Continue Reading]

Filed Under: News, Stroke Tagged With: blood pressure, Cardioprotective

Atrial fibrillation Prevent stroke, stop symptoms

You expected to sail through your yearly check-up. What you didn’t expect was a diagnosis of a heart rhythm problem called atrial fibrillation.

Atrial fibrillation occurs in about 1 percent of adults in their 60s. The incidence rate rises with age after that, with about 10 to 12 percent of people in their 80s having atrial fibrillation.

Atrial fibrillation may or may not cause symptoms. Either way, it can lead to development of blood clots in the heart that can break off and travel to the brain, where they can disrupt blood supply and cause a stroke.

About 15 percent of strokes are attributed to atrial fibrillation — and that number may be higher as undetected atrial fibrillation may be responsible for some of the roughly 25 percent of strokes that have no identifiable cause.

Whether you feel symptoms or not, it’s important to follow through with recommended treatments. These may include medications or surgery designed to help control or reset your heart rhythm, in addition to anti-clotting medications to prevent stroke.… [Continue Reading]

Filed Under: Stroke

Smokers Unaware of Tobacco’s Impact on Heart, Stroke Risk

By Shelley Wood

April 20, 2012 (Dubai, United Arab Emirates) — An international study is confirming what many cardiologists have known for a while–many smokers around the globe know that smoking can cause lung cancer, but far fewer are aware that their habit has adverse effects on the heart. Even more striking, smokers were largely unaware that secondhand smoke increases the risk of heart disease and stroke among nonsmokers.

The new numbers, unveiled by Dr Geoffrey T Fong (University of Waterloo, ON) at the World Congress of Cardiology (WCC) 2012, come from the International Tobacco Control (ITC) Policy Evaluation and the Global Tobacco Surveillance System (GTSS). Both, Fong noted to heartwire , provide strikingly similar snapshots of smokers’ perceptions of their own disease risk.… [Continue Reading]

Filed Under: Stroke

MRI Guides Diagnostic Approach for Ischaemic Stroke

M A Kumar; H Vangala; D C Tong; D M Campbell; A Balgude; I Eyngorn; A S Beraud; J M Olivot; A W Hsia; R A Bernstein; C A Wijman; M G Lansberg; M Mlynash; S Hamilton; M E Moseley; G W Albers

Background and aim Identification of ischaemic stroke subtype currently relies on clinical evaluation supported by various diagnostic studies. The authors sought to determine whether specific diffusion-weighted MRI (DWI) patterns could reliably guide the subsequent work-up for patients presenting with acute ischaemic stroke symptoms.

Methods 273 consecutive patients with acute ischaemic stroke symptoms were enrolled in this prospective, observational, single-centre NIH-sponsored study. Electrocardiogram, non-contrast head CT, brain MRI, head and neck magnetic resonance angiography (MRA) and transoesophageal echocardiography were performed in this prespecified order. Stroke neurologists determined TOAST (Trial of Org 10172 in Acute Stroke Treatment) classification on admission and on discharge. Initial TOAST stroke subtypes were compared with the final TOAST subtype. If the final subtype differed from the initial assessment, the diagnostic test deemed the principal determinant of change was recorded. These principal determinants of change were compared between a CT-based and an MRI-based classification schema.… [Continue Reading]

Filed Under: Stroke

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